SAN FRANCISCO 49ERS (10-4) INDIANAPOLIS COLTS (8-6)
Lucas Oil Stadium | Referee: Ron Torbert
All-Time Series History
Regular Season: IND leads series, 27-18 (IND won past 5)
Postseason: —
The Last Time…
Regular Season: 10/24/21: IND 30 at SF 18
Postseason: —
49ERS NOTES:
QB BROCK PURDY passed for 295 yards & 3 TDs for season-high 140.3 rating & had 44 rush yards in Week 15, his 7th career game with 140+ passer rating, tied-most (HOFer Kurt Warner) for most such games (min. 10 att. in each game) in 1st 4 seasons in NFL history. Has TD pass in all 6 games played this season. • RB CHRISTIAN MCCAFFREY had team-high 73 rush yards & TD in Week 15. Aims for 7th in row with 70+ scrimmage yards & 5th in row with TD. Ranks 3rd with 1,742 scrimmage yards & tied-3rd with 14 TDs this season & is 3rd player in NFL history (HOFer LaDainian Tomlinson – 6 seasons & Shaun Alexander – 5) with 1,600+ scrimmage yards & 13+ TDs in five career seasons. Had 173 scrimmage yards in last game vs. Ind. (12/22/19 w/ Car.). • WR JAUAN JENNINGS had team-high 2 TD catches last week & aims for 4th in row with TD reception. • WR RICKY PEARSALL led team with 96 rec. yards in Week 15. • TE GEORGE KITTLE had 8 receptions for 88 yards & TD in Week 15. Ranks tied-4th among TEs with 6 TD receptions this season. Has 7,864 rec. yards & 51 rec. TDs since 2017 & is 5th TE in NFL history with 7,500+ rec. yards & 50+ rec. TDs in 1st 9 seasons. • LB DEE WINTERS had 5 tackles & TFL in Week 15 & aims for 5th in row with 5+ tackles on road. • LB CURTIS ROBINSON had 7 tackles & 1st PD this season in Week 15 & has 6+ tackles in 3 of his past 4. • LB TATUM BETHUNE had 10+ tackles in 5 of his past 6 games. • DL KALIA DAVIS had 2nd PD this season in Week 15. • DB CLELIN FERRELL had 6 tackles in Week 15 & aims for 3rd in row with 6+ tackles. Has TFL in 2 of his past 3. • S MALIK MUSTAPHA led team with 10 tackles in Week 15 & aims for 4th in row with 7+ tackles. Has TFL in 2 of his past 3. Aims for 3rd in row on road with PD.
COLTS NOTES:
COLTS rank 2nd in AFC in scoring offense (28 points per game). • QB PHILIP RIVERS completed 18 of 27 atts. (66.7 pct.) for 120 yards & TD in Week 15, 1st career start since 2020. Has 225+ pass yards & TD pass in 5 of his past 6 on MNF. Is 4-0 in 4 career starts vs. SF & has 250+ pass yards & 2+ TD passes in each start. • RB JONATHAN TAYLOR led team with 101 scrimmage yards (87 rush, 14 rec.) last week. Leads NFL in rush yards (1,443), rush TDs (16), scrimmage TDs (18) & ranks 2nd in scrimmage yards (1,761) in 2025. Has 120+ scrimmage yards in 4 of his past 5 at Lucas Oil Stadium. Has 95+ scrimmage yards & rush TD in only 2 career games on MNF. Had 110 scrimmage yards (107 rush, 3 rec.) & rush TD in last meeting. • WR MICHAEL PITTMAN has 6+ catches, 60+ rec. yards & TD catch in 2 of his past 3 on MNF. Had 4 catches for 105 yards & TD in last meeting. • WR JOSH DOWNS had TD catch in Week 15. Has TD catch in 2 of his past 3 at Lucas Oil Stadium. • TE TYLER WARREN ranks 2nd among rookies in receptions (63) & ranks 4th among TEs in rec. yards (718) in 2025. Is 1 of 3 rookies (Emeka Egbuka & Harold Fannin) with 10 games with 4+ receptions. Has TD catch in 3 of his past 4 at Lucas Oil Stadium. • LB ZAIRE FRANKLIN had 10 tackles & TFL last week. Has 10+ tackles in 4 of his past 5. Aims for his 7th in row on MNF with 9+ tackles. • LB GERMAINE PRATT had 10 tackles & TFL in Week 15. Has PD in 5 of his past 6. Has 8+ tackles in each of his 3 games at Lucas Oil Stadium this season. Aims for his 3rd in row vs. SF with 5+ tackles & PD. • DE LAIATU LATU had 3 TFL & sack last week. • S NICK CROSS had 7 tackles & 1st FF of season in Week 15. • S CAM BYNUM had 8 tackles last week. Has TFL & PD in 2 of his past 3.
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