All-Time Series History
Regular Season: SF leads series, 77-70-3 (LAR won past 3)
Postseason: Series tied, 1-1
The Last Time…
Regular Season: 12/12/24: LAR 12 at SF 6
Postseason: Postseason: NFC-C 1/30/22: SF 17 at LAR 20
49ERS NOTES:
QB BROCK PURDY passed for 309 yards & 2 TDs last week, his 11th-career 300-yard game, 2nd-most in NFL since 2023. Aims for his 5th in row with 275+ pass yards & 2+ TD passes. Passed for 292 yards & 3 TDs vs. 0 INTs for 137.1 rating in last road meeting (9/22/24). • RB CHRISTIAN MCCAFFREY had 6 catches, 141 scrimmage yards (92 rec., 49 rush) & 31st-career rec. TD last week. Is 1 of 3 RBs (James Cook & Bijan Robinson) with 100+ scrimmage yards in each of 1st 4 weeks. Ranks 3rd in NFL in scrimmage yards (530) & receptions (31). Has 28 receptions (7 per game), 651 scrimmage yards (162.8 per game) & 5 TDs (4 rush, 1 rec.) in 4 career games vs. LAR, incl. 135+ scrimmage yards in each game. Aims for his 4th in row on Thursday with 115+ scrimmage yards & rush TD. • WR RICKY PEARSALL ranks 4th in NFL with 327 rec. yards in 2025 & has 50+ rec. yards in 5 of his past 6. Aims for his 8th in row with 4+ catches. • WR JAUAN JENNINGS has 50+ rec. yards in 4 of his past 5 on road. Had career highs in catches (11), rec. yards (175) & rec. TDs (3) in last road meeting (9/22/24). • TE JAKE TONGES had career-high 58 rec. yards & 2nd-career TD catch last week. • LB FRED WARNER had 8 tackles & 17th-career FF last week. Had 15 tackles in last meeting. Has PD in 4 of his past 5 vs. LAR. Has 79 tackles (8.8 per game) in 9 career Thursday games. • LB DEE WINTERS led team with career-high 10 tackles & had TFL & PD in Week 4. Aims for his 3rd in row with PD. • DL BRYCE HUFF has sack in 2 of his past 3 & aims for his 4th in row with TFL. • CB DEOMMODORE LENOIR aims for his 4th in row with TFL. Had 2 PD in last meeting. • S MARQUES SIGLE had career-best 8 tackles & 1st-career PD last week & is only rookie DB with 5+ tackles in each of 1st 4 weeks.
RAMS NOTES:
QB MATTHEW STAFFORD passed for 375 yards & 3 TDs vs. 0 INTs for 123.5 rating last week, his 18th-career game with 375+ pass yards. Aims for his 4th in row with 2+ TD passes. Has won 4 of his past 5 Thursday starts. • RB KYREN WILLIAMS had 94 scrimmage yards (77 rush, 17 rec.) last week & has 50+ scrimmage yards in 32 straight games, longest active streak in NFL. Has 12 TDs (10 rush, 2 rec.) in his past 10 at home. Has 328 scrimmage yards (109.3 per game) & 5 TDs (3 rush, 2 rec.) in 3 career games vs. SF, incl. 3 TDs (2 rush, 1 rec.) in last home meeting (9/22/24). Aims for his 4th in row on Thursday with 100+ scrimmage yards. • WR PUKA NACUA had 13 receptions for career-high 170 yards & 10th-career TD catch last week, his 7th-career game with 10+ catches & 100+ rec. yards. Became 2nd player ever (Cooper Kupp – 2022) with 10+ catches & 100+ rec. yards in 3 of his team’s 1st 4 games of season. Leads NFL with 42 receptions, tied-most by player in team’s 1st 4 games of season all-time. Had career-high 15 receptions for 147 yards in his only career home game vs. SF (9/17/23). • WR DAVANTE ADAMS aims for his 4th in row with rec. TD & 5th in row with 50+ rec. yards. Has 106 career reg. season rec. TDs, tied with Mike Evans for most among active players & tied 9th-most in NFL history. Has 46 receptions (9.2 per game) for 633 yards (126.6 per game) & 7 rec. TDs in 5 career games vs. SF, with rec. TD in each game & 7+ catches & 130+ rec. yards in 4 of 5 games. • LB BYRON YOUNG is 1 of 2 (Brian Burns) with sack in each of 1st 4 weeks. Has sack in 3 of his 4 career games vs. SF & aims for his 4th in row vs. SF with TFL. • LB JARED VERSE aims for his 3rd in row with sack & FF. • DE KOBIE TURNER had 2 sacks in last meeting. • S KAM CURL had career-high 3 PD & 1st-career game with 2 INTs last week. Aims for his 7th in row with 5+ tackles. Had 2 PD in last meeting. • S QUENTIN LAKE had 2 PD in last meeting. Aims for his 4th in row with 5+ tackles.
RAMS LOOK TO EXTEND WINNING STREAK OVER RIVAL 49ERS ON THURSDAY NIGHT
San Francisco (3-1) at Los Angeles Rams (3-1)
Thursday, 8:15 p.m. EDT, Prime Video
BetMGM NFL Odds: Rams by 7
Against the spread: 49ers 2-2; Rams 3-1
Series record: 49ers lead 78-71-3.
Last meeting: Rams beat 49ers 12-6 in Santa Clara, California on Dec. 12, 2024.
Last week: 49ers lost to Jaguars 26-21; Rams beat Colts 27-20.
49ers offense: overall (5), rush (28), pass (2), scoring (23).
49ers defense: overall (T-5), rush (17), pass (6), scoring (7).
Rams offense: overall (4), rush (13), pass (3), scoring (13).
Rams defense: overall (9), rush (10), pass (T-9), scoring (T-10).
Turnover differential: 49ers minus-5; Rams plus-3.
49ers player to watch
RB Christian McCaffrey. McCaffrey had 92 yards receiving last week for his most since joining the Niners. He is one of four players in the league with at least 100 yards from scrimmage in every game this season. The only 49ers players to do it in each of the first five games in a season are Roger Craig (1988) and Paul Hofer (1980).
Rams player to watch
WR Puka Nacua had 13 receptions for a career-high 170 yards and a touchdown against the Colts, his third game this season with at least 10 receptions and 100 yards. Nacua leads the league in receptions (42) and yards receiving (503), and he has at least 118 yards from scrimmage in each of the first four games. In three games against San Francisco, he has 26 receptions for 285 yards and one touchdown.
Key matchup
Rams QB Matthew Stafford vs. 49ers defense. When the 37-year-old Stafford gets in a rhythm, as he did in a two-minute drill at the end of the first half or on the game-tying touchdown drive in the fourth quarter, there might not be a better passer in football. That is why San Francisco will need big efforts from its pass rush and secondary to disrupt Stafford’s timing with Nacua and Davante Adams. The 49ers have five sacks through four games and failed to sack the Jaguars’ Trevor Lawrence on Sunday, while the defensive backs held Jacksonville to a single pass play of more than 20 yards.
Key injuries
49ers: QB Brock Purdy is questionable this week with a sore toe. Purdy missed two games because of the injury before returning last week but had soreness after the game. Mac Jones would make his third start if Purdy can’t play. … WR Ricky Pearsall (knee) and WR Jauan Jennings (ribs, ankle) are also questionable for the game. … CB Renardo Green could return after missing the previous game with a neck injury.
Rams: LG Steve Avila (ankle) was active but didn’t play against Indianapolis. Whether he is healthy enough to regain his spot in the starting lineup this week isn’t clear. … RT Rob Havenstein (ankle) and TE Tyler Higbee (hip) have not practiced this week but the veterans should be good to go, albeit at less than 100%.
Series notes
The Rams have won three straight over their Bay Area rivals following a nine-game regular-season losing streak. … Each of those three Los Angeles wins have been by six points or fewer. … San Francisco coach Kyle Shanahan is 10-7 against his friend and former colleague Sean McVay.
Stats and stuff
San Francisco has won two division games to open this season after going 1-5 vs. the NFC West last season. … The 49ers have held opponents to a 32% conversion rate on third down for the second-best mark in the NFL. … San Francisco has no TD runs through four games for the first time since 1990. … The 49ers have tied an NFL record set last season by the Giants by going 11 straight games without intercepting a pass. … The 49ers have been outrushed by 27.5 yards per game, their worst mark through four games since 2010 when they were minus-29.3. … San Francisco had no sacks and no QB hits last week for the first time since Week 2 of the 2015 season. … LB Fred Warner had his 17th career forced fumble last week for the most by a Niners player since at least 1994. … The Rams have allowed 86 and 85 yards rushing in their past two games. They most recently held three straight opponents under 100 yards in Week 11-13 of the 2023 season. … Stafford needs 11 completions to pass Philip Rivers (5,277) for eight in NFL history for completions. … Nacua has 42 receptions and is tied with Cooper Kupp and Michael Thomas for most through four games in league history. … Los Angeles has scored eight touchdowns in 16 red zone drives, including five touchdowns in nine goal-to-go situations (55.6%). … OLB Byron Young has at least one sack in each game this season, and his five total sacks is tied with the Giants’ Brian Burns for the league lead.
Fantasy tip
The distribution of touches between Rams RB Kyren Williams (13 carries, three receptions) and Blake Corum (nine carries, two receptions) versus the Colts might have given fantasy owners pause. Williams was much more effective, finishing with 94 yards from scrimmage, and the game plan may not be so pass heavy every week, so it’s not worth worrying about going forward.
